CD45RB anticorps

N° du produit ABIN7880313

L’anticorps anti-CD45RB Monoclonal Souris est utilisé pour la détection de CD45RB dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour CD45RB anticorps (ABIN7880313)

Antigène: CD45RB

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD45RB est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM569

Détail du produit anti-CD45RB anticorps

Fonction: Anti-CD45RB Antibody

Purification: Protein G affinity chromatography

Immunogène: Human peripheral blood lymphocytes maintained in T cell growth factor were used as the immunogen for this anti-CD45RB antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The optimal dilution of the anti-CD45RB antibody for each application should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10 mM Tris with 1 mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the anti-CD45RB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur CD45RB

Antigène: CD45RB

Autre désignation: CD45RB

Sujet: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

UniProt: P08575