CD46 anticorps

N° du produit ABIN7880327

Cet anticorps Souris Monoclonal détecte spécifiquement CD46 dans WB, FACS et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CD46 anticorps (ABIN7880327)

Antigène: CD46

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 9E9-

Détail du produit anti-CD46 anticorps

Fonction: CD46 Antibody

Séquence: YRYLQRRKKK GTYLTDETHR EVKFTSL

Purification: Affinity purified

Immunogène: Amino acids YRYLQRRKKKGTYLTDETHREVKFTSL from the human protein were used as the immunogen for the CD46 antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the CD46 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the CD46 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur CD46

Antigène: CD46

Autre désignation: CD46

Sujet: CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. And the encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization