Claudin 16 anticorps

N° du produit ABIN7880445

L’anticorps anti-Claudin 16 Polyclonal Lapin est utilisé pour la détection de Claudin 16 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, FACS et IF.

Aperçu rapide pour Claudin 16 anticorps (ABIN7880445)

Antigène: Claudin 16 (CLDN16)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claudin 16 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-Claudin 16 anticorps

Fonction: Claudin 16 Antibody / CLDN16

Séquence: KSYSAPRTET AKMYAVDTRV

Purification: Affinity purified

Immunogène: Amino acids KSYSAPRTETAKMYAVDTRV from the human protein were used as the immunogen for the Claudin 16 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Claudin 16 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Claudin 16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Claudin 16

Antigène: Claudin 16 (CLDN16)

Autre désignation: Claudin 16

Sujet: Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.

UniProt: Q9Y5I7

Pathways: Hepatitis C