Recombinant CDSE1 anticorps

N° du produit ABIN7880471

Cet anticorps Lapin Monoclonal détecte spécifiquement CDSE1 dans WB et IP. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant CDSE1 anticorps (ABIN7880471)

Antigène: CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CDSE1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: 30C76

Détail du produit anti-CDSE1 anticorps

Fonction: CSDE1 Antibody / Cold shock domain containing E1

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human CSDE1 was used as the immunogen for the CSDE1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the CSDE1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the CSDE1 antibody at -20oC.

Détails sur CDSE1

Antigène: CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))

Autre désignation: CSDE1

Sujet: CSDE1 antibody detects cold shock domain containing E1, an RNA-binding protein also known as UNR (upstream of N-ras). CSDE1 contains multiple cold shock domains that allow it to interact with RNA and regulate processes such as translation, RNA stability, and internal ribosome entry site (IRES)-mediated initiation. Its wide influence on gene expression positions CSDE1 as a key regulator of cellular adaptation and developmental programs.

Research using CSDE1 antibody has linked the protein to diverse biological processes. In embryogenesis, CSDE1 regulates translation of transcripts required for cell differentiation. In cancer, aberrant CSDE1 activity promotes tumor progression by stabilizing oncogenic mRNAs and enhancing their translation. Studies have shown that high CSDE1 expression is associated with melanoma, prostate cancer, and neuroblastoma, highlighting its role in malignancy. Conversely, CSDE1 also regulates apoptosis-related transcripts, underscoring its complex function in cell fate control.

CSDE1 has additional roles in viral biology, where it regulates the translation of viral RNAs that depend on IRES elements. Viruses such as poliovirus and hepatitis C exploit CSDE1 to enhance replication. Its dual function in host and viral RNA regulation makes it a subject of interest in infection research. In neurons, CSDE1 has been implicated in local translation within axons and dendrites, influencing synaptic plasticity and neuronal survival.

Antibodies against CSDE1 are validated for western blot, immunoprecipitation, immunofluorescence, and immunohistochemistry. These reagents allow detection of CSDE1 expression patterns, RNA-binding activities, and protein interactions. Clone-based antibodies provide high specificity for reproducible results across systems.

NSJ Bioreagents supplies this CSDE1 antibody for research into RNA regulation, cancer biology, and virology.

UniProt: O75534

Pathways: SARS-CoV-2 Protein Interactome