Recombinant DCAF13 anticorps

N° du produit ABIN7880606

Cet anticorps Lapin Monoclonal détecte spécifiquement DCAF13 dans WB, IHC et IP. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant DCAF13 anticorps (ABIN7880606)

Antigène: DCAF13 (DDB1 and CUL4 Associated Factor 13 (DCAF13))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp DCAF13 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 32D85

Détail du produit anti-DCAF13 anticorps

Fonction: DCAF13 Antibody / DDB1- and CUL4-associated factor 13

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human DCAF13 was used as the immunogen for the DCAF13 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the DCAF13 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the DCAF13 antibody at -20oC.

Détails sur DCAF13

Antigène: DCAF13 (DDB1 and CUL4 Associated Factor 13 (DCAF13))

Autre désignation: DCAF13

Sujet: DCAF13 antibody detects DDB1- and CUL4-associated factor 13, encoded by the DCAF13 gene. DDB1- and CUL4-associated factor 13 is a substrate receptor for the CUL4-DDB1 E3 ubiquitin ligase complex, directing ubiquitination and degradation of specific proteins. DCAF13 antibody provides researchers with a key reagent to study ubiquitin-mediated proteolysis, cell cycle regulation, and cancer biology.

DDB1- and CUL4-associated factor 13 belongs to the family of WD repeat proteins that serve as adaptors for CUL4-based E3 ligases. Research using DCAF13 antibody has shown that it recognizes substrates and recruits them to the ligase complex, ensuring precise turnover of proteins that regulate transcription and cell cycle progression. This function is critical for maintaining protein homeostasis and genomic stability.

Studies with DCAF13 antibody have revealed that it plays roles in embryonic development and tumorigenesis. In embryonic cells, DCAF13 supports proliferation by targeting key regulators of transcription and signaling for degradation. In cancers, overexpression of DCAF13 enhances tumor growth and survival by destabilizing tumor suppressor proteins. These observations highlight the importance of DDB1- and CUL4-associated factor 13 in growth control and oncogenesis.

DCAF13 has also been implicated in stress responses. Research using DCAF13 antibody has demonstrated that the protein participates in DNA damage repair pathways, regulating protein stability during genotoxic stress. By coordinating protein turnover with DNA repair, DCAF13 contributes to genome integrity.

DCAF13 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects endogenous protein levels, immunohistochemistry reveals expression in proliferative tissues, and immunofluorescence highlights nuclear localization consistent with transcriptional regulation. These approaches make DCAF13 antibody valuable for investigating ubiquitin signaling and cancer biology.

By supplying validated DCAF13 antibody reagents, NSJ Bioreagents supports research into protein degradation, cell cycle regulation, and oncogenesis. Detection of DDB1- and CUL4-associated factor 13 provides insights into how E3 ligase adaptors regulate cellular function and disease.

UniProt: Q9NV06