Desmoglein 1 anticorps

N° du produit ABIN7880620

Cet anticorps anti-Desmoglein 1 Monoclonal Souris (Clone 32-2B) (ABIN7880620) détecte spécifiquement Desmoglein 1 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Desmoglein 1 anticorps (ABIN7880620)

Antigène: Desmoglein 1 (DSG1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: 32-2B

Détail du produit anti-Desmoglein 1 anticorps

Fonction: Desmoglein 1 Antibody / DSG1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Bovine desmoglein (desmosomal glyco protein I) from nasal epidermis was used as the immunogen for the Desmoglein 1 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the Desmoglein 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Desmoglein 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Desmoglein 1

Antigène: Desmoglein 1 (DSG1)

Autre désignation: Desmoglein 1

Sujet: Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

UniProt: Q02413

Pathways: Cell-Cell Junction Organization