Desmoglein 1 anticorps

N° du produit ABIN7880621

Cet anticorps Souris Monoclonal détecte spécifiquement Desmoglein 1 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Desmoglein 1 anticorps (ABIN7880621)

Antigène: Desmoglein 1 (DSG1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 32-2B

Détail du produit anti-Desmoglein 1 anticorps

Fonction: Desmoglein 1 Antibody / DSG1

Purification: Protein G affinity chromatography

Immunogène: Bovine desmoglein (desmosomal glyco protein I) from nasal epidermis was used as the immunogen for the Desmoglein 1 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the Desmoglein 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Desmoglein 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Desmoglein 1

Antigène: Desmoglein 1 (DSG1)

Autre désignation: Desmoglein 1

Sujet: Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

UniProt: Q02413

Pathways: Cell-Cell Junction Organization