DCLK1 anticorps

N° du produit ABIN7880654

Cet anticorps Lapin Monoclonal détecte spécifiquement DCLK1 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DCLK1 anticorps (ABIN7880654)

Antigène: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp DCLK1 est non-conjugé

Application: Western Blotting (WB)

Clone: AAFA-4

Détail du produit anti-DCLK1 anticorps

Fonction: DCLK1 Antibody / Doublecortin-like kinase 1

Purification: Affinity purified

Immunogène: A synthetic peptide specific to human Doublecortin-like kinase 1 was used as the immunogen for the DCLK1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the DCLK1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the DCLK1 antibody at -20oC.

Détails sur DCLK1

Antigène: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Autre désignation: DCLK1

Sujet: The DCKL1 gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [RefSeq]

UniProt: O15075