Recombinant ERG anticorps

N° du produit ABIN7880734

Cet anticorps anti-ERG Monoclonal Souris (Clone rERG-6843) (ABIN7880734) détecte spécifiquement ERG dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant ERG anticorps (ABIN7880734)

Antigène: ERG (ERG, ETS transcription factor (ERG))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ERG est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: RERG-6843

Détail du produit anti-ERG anticorps

Fonction: Transcriptional regulator ERG Antibody / ERG (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 450 to 479 was used as the immunogen for the Transcriptional regulator ERG antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Transcriptional regulator ERG antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Transcriptional regulator ERG antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur ERG

Antigène: ERG (ERG, ETS transcription factor (ERG))

Autre désignation: Transcriptional regulator ERG

Sujet: ERG (ETS-related gene) is a proto-oncogene, a member of the ETS family of transcription factors. The ERG gene encodes for a nuclear protein, also called ERG, which is involved in hematopoietic and endothelial development. ERG remains constitually expressed in endothelial cells in blood and lymphatic vessels, and in bone marrow stem cells. ERG is expressed in virtually all endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma. ERG is overexpressed secondary to gene rearrangement in cases of prostate adenocarcinoma, gastrointestinal stromal tumor, synovial sarcoma, meningioma, epithelioid sarcoma, malignant rhabdoid tumor, acute myeloid leukemia and blastic extramedullary myeloid tumor, and rarely Ewing sarcoma / primitive peripheral neuroectodermal tumor, chondrosarcoma, osteosarcoma, and rhabdomyosarcoma. For the identification of endothelial differentiation ERG seems more sensitive and specific than any other marker. Moreover, the interpretation is often easier due to the nuclear reaction, which also allows for double stains with cytoplasmic markers like podoplanin. Among carcinomas, ERG is highly specific for prostate, while the sensitivity is moderate.

UniProt: P11308