Recombinant EIF3A anticorps

N° du produit ABIN7880749

Cet anticorps anti-EIF3A Monoclonal Lapin (Clone 31E29) (ABIN7880749) détecte spécifiquement EIF3A dans WB, IHC, IF et ICC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant EIF3A anticorps (ABIN7880749)

Antigène: EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp EIF3A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 31E29

Détail du produit anti-EIF3A anticorps

Fonction: EIF3A Antibody / Eukaryotic translation initiation factor 3 subunit A

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human eIF3A was used as the immunogen for the EIF3A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the EIF3A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the EIF3A antibody at -20oC.

Détails sur EIF3A

Antigène: EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))

Autre désignation: EIF3A

Sujet: EIF3A antibody detects eukaryotic translation initiation factor 3 subunit A, the largest subunit of the EIF3 complex. EIF3A is a central scaffold protein that coordinates the assembly of other EIF3 subunits, promoting formation of the 43S preinitiation complex. This step is essential for recruiting mRNA and initiating protein synthesis. EIF3A contributes to translation of specific mRNAs involved in cell cycle progression, signaling, and stress adaptation.

Research using EIF3A antibody has highlighted the protein's role in both normal cellular growth and cancer biology. EIF3A is frequently overexpressed in tumors, where it selectively enhances translation of oncogenes and suppresses translation of tumor suppressors. This imbalance contributes to tumor proliferation, survival, and metastasis. Studies have linked EIF3A to lung cancer, breast cancer, and hepatocellular carcinoma, making it a valuable biomarker and potential therapeutic target.

Beyond cancer, EIF3A is essential for embryonic development and cellular stress responses. Its regulation ensures that cells adapt translation rates during nutrient deprivation, hypoxia, or DNA damage. EIF3A dysfunction disrupts protein homeostasis, leading to impaired cell survival or uncontrolled growth. Because of this, EIF3A has become an important research focus in studies of translation control and disease mechanisms.

Antibodies against EIF3A are validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation. These reagents enable researchers to monitor EIF3A protein levels, examine subcellular localization, and analyze interactions within the EIF3 complex. Clone-based versions provide specificity required to distinguish EIF3A from other EIF3 subunits.

NSJ Bioreagents supplies this EIF3A antibody to support research in translation initiation, cancer pathways, and developmental biology.

UniProt: Q14152

Pathways: Ribonucleoprotein Complex Subunit Organization