Recombinant EXOC2 anticorps

N° du produit ABIN7880755

Cet anticorps anti-EXOC2 Monoclonal Lapin (Clone 31E49) (ABIN7880755) détecte spécifiquement EXOC2 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant EXOC2 anticorps (ABIN7880755)

Antigène: EXOC2 (Exocyst Complex Component 2 (EXOC2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp EXOC2 est non-conjugé

Application: Western Blotting (WB)

Clone: 31E49

Détail du produit anti-EXOC2 anticorps

Fonction: EXOC2 Antibody / Exocyst complex component 2

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human EXOC2 was used as the immunogen for the EXOC2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the EXOC2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the EXOC2 antibody at -20oC.

Détails sur EXOC2

Antigène: EXOC2 (Exocyst Complex Component 2 (EXOC2))

Autre désignation: EXOC2

Sujet: EXOC2 antibody detects exocyst complex component 2, a critical member of the octameric exocyst complex that regulates tethering of secretory vesicles to the plasma membrane. This protein, also known as Sec5, functions in exocytosis and polarized trafficking, ensuring cargo delivery to specific membrane domains. By organizing vesicle docking, EXOC2 plays a fundamental role in processes such as cell migration, epithelial polarity, and neurite outgrowth. Its interactions with Ral GTPases highlight its role in small GTPase-mediated trafficking control.

Research using EXOC2 antibody has connected this protein to cancer and neurological disorders. Overexpression of EXOC2 has been reported in several tumor types, where it may promote invasive behavior by enhancing targeted membrane addition and secretion of proteases. In neurons, altered exocyst function has been linked to impaired synaptic vesicle recycling and neurodevelopmental defects. Investigating EXOC2 therefore provides insight into both normal cellular organization and disease pathology.

Antibodies against EXOC2 have been validated in western blot, immunohistochemistry, and immunoprecipitation. These tools help characterize exocyst assembly, subcellular localization, and interactions with signaling proteins. High-specificity clones are particularly valuable for distinguishing EXOC2 from related exocyst components within large multiprotein complexes.

NSJ Bioreagents supplies this EXOC2 antibody for research applications in membrane trafficking, cancer biology, and neurobiology. Alternate names include exocyst complex component 2 antibody, Sec5 antibody, SEC5L1 antibody, and Sec5p antibody.

UniProt: Q96KP1

Pathways: Peptide Hormone Metabolism, Regulation of Actin Filament Polymerization, Synaptic Vesicle Exocytosis