Recombinant FAM50A anticorps

N° du produit ABIN7880762

Cet anticorps Lapin Monoclonal détecte spécifiquement FAM50A dans WB, IHC, IF et ICC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant FAM50A anticorps (ABIN7880762)

Antigène: FAM50A (Family with Sequence Similarity 50, Member A (FAM50A))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp FAM50A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 30F36

Détail du produit anti-FAM50A anticorps

Fonction: FAM50A Antibody / Family with sequence similarity 50 member A

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human FAM50A was used as the immunogen for the FAM50A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the FAM50A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the FAM50A antibody at -20oC.

Détails sur FAM50A

Antigène: FAM50A (Family with Sequence Similarity 50, Member A (FAM50A))

Autre désignation: FAM50A

Sujet: FAM50A antibody detects family with sequence similarity 50 member A, a nuclear protein involved in RNA processing and gene expression regulation. FAM50A is ubiquitously expressed and localized primarily to the nucleoplasm, where it associates with spliceosomal components and contributes to pre-mRNA splicing. Though relatively understudied compared to other RNA-binding proteins, evidence suggests FAM50A plays an important role in transcriptional control and cellular homeostasis.

Research using FAM50A antibody has linked the protein to development and disease. Genetic studies reveal that mutations in FAM50A cause Armfield X-linked intellectual disability syndrome, characterized by developmental delay, dysmorphic features, and neurobehavioral abnormalities. The disorder underscores FAM50A's significance in neurodevelopment and proper RNA processing. Knockout models further demonstrate embryonic lethality or severe neurological phenotypes, confirming its essential role.

Beyond development, FAM50A has been implicated in cancer biology. Altered expression is observed in several tumor types, where it may influence splicing decisions and transcriptional programs that favor proliferation. Transcriptome studies suggest that dysregulation of FAM50A perturbs global RNA processing networks, contributing to oncogenic transformation.

At the molecular level, FAM50A interacts with spliceosome-associated proteins, ribonucleoprotein complexes, and chromatin regulators. These interactions suggest a broader role in coupling transcription to RNA maturation. Additional evidence connects FAM50A to cell cycle control, where depletion disrupts proliferation and induces apoptosis.

Antibodies against FAM50A are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents enable detection of FAM50A in tissue and cell culture, supporting research into RNA biology, neurodevelopment, and tumorigenesis. Clone-based antibodies ensure reproducibility and specificity across experimental conditions.

NSJ Bioreagents offers this FAM50A antibody for research into RNA processing, gene regulation, and disease.

UniProt: Q14320