Recombinant FRG1 anticorps

N° du produit ABIN7880823

L’anticorps anti-FRG1 Monoclonal Lapin est utilisé pour la détection de FRG1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IF et ICC.

Aperçu rapide pour Recombinant FRG1 anticorps (ABIN7880823)

Antigène: FRG1 (FSHD Region Gene 1 (FRG1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp FRG1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 32F07

Détail du produit anti-FRG1 anticorps

Fonction: FRG1 Antibody / FSHD region gene 1

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human FRG1 was used as the immunogen for the FRG1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the FRG1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the FRG1 antibody at -20oC.

Détails sur FRG1

Antigène: FRG1 (FSHD Region Gene 1 (FRG1))

Autre désignation: FRG1

Sujet: FRG1 antibody detects FSHD region gene 1 protein, encoded by the FRG1 gene. This protein is associated with RNA processing, pre-mRNA splicing, and actin cytoskeleton organization. FRG1 antibody provides researchers with a critical reagent for investigating muscular dystrophy, RNA metabolism, and nuclear architecture. Interest in FRG1 intensified because of its location within the genomic region associated with facioscapulohumeral muscular dystrophy (FSHD), a progressive muscle wasting disease.

FSHD region gene 1 protein is expressed in both nuclear and cytoplasmic compartments. In the nucleus, it associates with splicing machinery and contributes to RNA maturation. Research using FRG1 antibody has demonstrated that overexpression of FRG1 alters splicing of muscle-specific transcripts, contributing to muscle pathology. In the cytoplasm, FRG1 interacts with actin filaments, influencing cytoskeletal organization and cell motility. These dual roles highlight its broad impact on cellular function.

Overexpression of FRG1 has been shown to produce muscular dystrophy-like phenotypes in model organisms. Studies with FRG1 antibody have confirmed that excessive expression disrupts muscle development, leading to muscle weakness and degeneration. This evidence supports the hypothesis that misregulation of FRG1 contributes to FSHD pathology. Conversely, controlled levels of FRG1 appear necessary for normal muscle and vascular development, linking its regulation to tissue homeostasis.

Beyond muscular dystrophy, FRG1 has been implicated in angiogenesis and vascular biology. Research with FRG1 antibody has revealed that it influences endothelial cell migration and capillary formation. Dysregulation of FRG1 may therefore contribute to vascular defects in addition to muscle abnormalities. This broadens the biological significance of FSHD region gene 1 protein to multiple tissues and disease processes.

FRG1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting identifies both endogenous and overexpressed FRG1, immunohistochemistry localizes it in muscle tissue, and immunofluorescence shows colocalization with nuclear speckles and actin filaments. These applications make FRG1 antibody indispensable for muscular dystrophy research.

By supplying validated FRG1 antibody reagents, NSJ Bioreagents supports studies of RNA processing, muscle disease, and cytoskeletal organization. Detection of FSHD region gene 1 protein provides insight into how RNA and cytoskeletal regulation intersect in development and pathology.

UniProt: Q14331