Recombinant GRSF1 anticorps

N° du produit ABIN7880840

Cet anticorps Lapin Monoclonal détecte spécifiquement GRSF1 dans WB, IF, IHC, ICC et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant GRSF1 anticorps (ABIN7880840)

Antigène: GRSF1 (G-Rich RNA Sequence Binding Factor 1 (GRSF1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp GRSF1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 30G49

Détail du produit anti-GRSF1 anticorps

Fonction: GRSF1 Antibody / G-rich RNA sequence-binding factor 1

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human GRSF1 was used as the immunogen for the GRSF1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GRSF1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the GRSF1 antibody at -20oC.

Détails sur GRSF1

Antigène: GRSF1 (G-Rich RNA Sequence Binding Factor 1 (GRSF1))

Autre désignation: GRSF1

Sujet: GRSF1 antibody is designed to detect G-rich RNA sequence-binding factor 1, a multifunctional RNA-binding protein localized primarily to the mitochondria and nucleolus. GRSF1 plays a critical role in RNA metabolism, including RNA stabilization, processing, and translation. It is particularly important for mitochondrial RNA handling, where it binds G-rich elements and supports the maturation of mitochondrial transcripts required for oxidative phosphorylation. As a result, GRSF1 is an essential factor for maintaining mitochondrial protein synthesis and energy production.

GRSF1 antibody is widely employed in studies of RNA biology, mitochondrial function, and stress responses. Disruption of GRSF1 has been associated with impaired mitochondrial gene expression and respiratory chain defects, leading to compromised energy metabolism. Researchers use GRSF1 antibody to track changes in expression and localization under different cellular conditions, including oxidative stress and disease models that affect mitochondrial integrity.

Applications of GRSF1 antibody include western blotting, immunohistochemistry, and immunofluorescence. In western blot assays, the antibody specifically recognizes GRSF1 protein bands, allowing for accurate comparisons of expression levels across experimental conditions. Immunohistochemistry provides tissue-level localization, while immunofluorescence highlights its mitochondrial distribution patterns in cultured cells. These techniques allow researchers to connect RNA-binding activity with mitochondrial homeostasis and gene expression.

GRSF1 also functions in the nucleolus, where it contributes to ribosomal RNA processing. This dual localization underscores its multifunctional role in RNA biology, linking mitochondrial gene expression with nuclear RNA processing pathways. By using GRSF1 antibody, researchers gain a powerful tool for exploring these interconnected processes.

In disease contexts, GRSF1 expression has been implicated in cancer and neurodegeneration. Altered RNA-binding activity may disrupt translation and contribute to disease pathology. Additionally, its role in mitochondrial maintenance makes it highly relevant for disorders involving energy metabolism and oxidative stress. Monitoring GRSF1 with specific antibodies allows for mechanistic studies that explore how RNA-binding proteins influence disease pathways.

GRSF1 antibody from NSJ Bioreagents offers reliable detection across multiple experimental methods, ensuring accurate analysis of this essential RNA-binding factor. Its proven specificity supports detailed investigations of RNA processing, mitochondrial function, and cellular stress adaptation.

UniProt: Q12849