GJB2 anticorps

N° du produit ABIN7880853

L’anticorps anti-GJB2 Polyclonal Lapin est utilisé pour la détection de GJB2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et FACS.

Aperçu rapide pour GJB2 anticorps (ABIN7880853)

Antigène: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GJB2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-GJB2 anticorps

Fonction: GJB2 Antibody / Connexin 26

Séquence: FYVMYDGFSM QRLVKCN

Purification: Antigen affinity purified

Immunogène: Amino acids FYVMYDGFSMQRLVKCN from the human protein were used as the immunogen for the GJB2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GJB2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the GJB2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur GJB2

Antigène: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Autre désignation: GJB2

Sujet: Connexin26 (CX26), also known as GAP junction protein, beta2, GJB2. Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence. The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD. CX26 shares 92.5 % identity with rat Cx26. connexin 26(GJB2) is assigned to human chromosome 13q11-q12 .Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. Connexin 26 gene(GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation.

UniProt: P29033

Pathways: Sensory Perception of Sound, Cell-Cell Junction Organization