CA 19-9 anticorps

N° du produit ABIN7880855

Cet anticorps Souris Monoclonal détecte spécifiquement CA 19-9 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CA 19-9 anticorps (ABIN7880855)

Antigène: CA 19-9 (Gastrointestinal Cancer Antigen CA19-9 (CA 19-9))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CA 19-9 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM588

Détail du produit anti-CA 19-9 anticorps

Fonction: CA19-9 Antibody

Purification: PEG precipitation

Immunogène: Precipitin lines obtained after immuno-diffusion using mAb 116-NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient (0Le) were used as the immunogen for the CA19-9 antibody.

Isotype: IgM, kappa

Information d'application

Indications d'application: Optimal dilution of the CA19-9 antibody should be determined by the researcher.

1. No special pretreatment is required for the immunohistochemical staining of formalin-fixed, paraffin-embedded tissues
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the CA19-9 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur CA 19-9

Antigène: CA 19-9 (Gastrointestinal Cancer Antigen CA19-9 (CA 19-9))

Autre désignation: CA19-9

Sujet: CA19-9, a carbohydrate epitope expressed on a high MW (>400 kDa) mucin glycoprotein, is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings. This mAb is superb for staining of formalin-fixed, paraffin-embedded tissues.