Recombinant HAUS7 anticorps

N° du produit ABIN7880957

Cet anticorps Lapin Monoclonal détecte spécifiquement HAUS7 dans WB, IHC et IP. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant HAUS7 anticorps (ABIN7880957)

Antigène: HAUS7 (HAUS Augmin-Like Complex, Subunit 7 (HAUS7))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp HAUS7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 30H47

Détail du produit anti-HAUS7 anticorps

Fonction: HAUS7 Antibody / UCHL5IP

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human UCHL5IP was used as the immunogen for the HAUS7 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the HAUS7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the HAUS7 antibody at -20oC.

Détails sur HAUS7

Antigène: HAUS7 (HAUS Augmin-Like Complex, Subunit 7 (HAUS7))

Autre désignation: HAUS7

Sujet: HAUS7 antibody detects HAUS augmin-like complex subunit 7, a protein encoded by the HAUS7 gene that contributes to mitotic spindle organization. HAUS7 is part of the augmin complex, an eight-subunit assembly that recruits gamma tubulin ring complexes to existing microtubules, amplifying spindle microtubule formation during mitosis. This process ensures accurate chromosome alignment and segregation, supporting genomic stability.

HAUS7 antibody is widely used in cell biology and cancer research. The augmin complex promotes branching microtubule nucleation, a mechanism essential for robust spindle assembly in dividing cells. By detecting HAUS7, researchers can study how spindle architecture is generated and maintained. Disruption of augmin components leads to spindle defects, chromosome missegregation, and aneuploidy, processes often linked to tumorigenesis.

Western blot assays detect HAUS7 protein bands in dividing cell extracts. Immunohistochemistry highlights HAUS7 expression in proliferative tissues, while immunofluorescence maps localization at mitotic spindles. These approaches allow detailed analysis of augmin function in cell division.

HAUS7 and other augmin subunits play roles in neural stem cell division, embryonic development, and tissue regeneration. Their contribution to faithful chromosome segregation highlights their importance for preventing genomic instability and disease. By applying HAUS7 antibody, scientists can investigate mechanisms linking spindle regulation to cancer and developmental disorders.

HAUS7 antibody from NSJ Bioreagents provides dependable specificity for studying microtubule nucleation and spindle organization. Its strong performance across methods ensures accurate detection in diverse research contexts.

UniProt: Q99871