ATRX anticorps

N° du produit ABIN7880992

Cet anticorps anti-ATRX Monoclonal Souris (Clone 23c) (ABIN7880992) détecte spécifiquement ATRX dans ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ATRX anticorps (ABIN7880992)

Antigène: ATRX (helicase 2, X-linked (ATRX))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATRX est non-conjugé

Application: ELISA

Classe de qualité: Carrier-free

Clone: 23c

Détail du produit anti-ATRX anticorps

Fonction: ATRX Antibody / RAD54 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Recombinant human ATRX protein was used as the immunogen for this ATRX antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the ATRX antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the ATRX antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur ATRX

Antigène: ATRX (helicase 2, X-linked (ATRX))

Autre désignation: ATRX

Sujet: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, it contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, it predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 i± to mediate chromosomal segregation. Mutations in the gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with alpha-thalassemia or ATRX syndrome.

UniProt: P46100