Recombinant HN1 anticorps

N° du produit ABIN7881004

Cet anticorps anti-HN1 Monoclonal Lapin (Clone 31J27) (ABIN7881004) détecte spécifiquement HN1 dans WB, FACS, IF et ICC. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Recombinant HN1 anticorps (ABIN7881004)

Antigène: HN1 (Hematological and Neurological Expressed 1 (HN1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp HN1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 31J27

Détail du produit anti-HN1 anticorps

Fonction: HN1 Antibody / JPT1 / Hematological and neurological expressed 1

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human HN1 was used as the immunogen for the HN1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the HN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the HN1 antibody at -20oC.

Détails sur HN1

Antigène: HN1 (Hematological and Neurological Expressed 1 (HN1))

Autre désignation: HN1

Sujet: HN1 antibody detects Hematological and neurological expressed 1, encoded by the HN1 gene. HN1 is a conserved protein expressed in many tissues and has been implicated in cell growth, differentiation, and signaling. Although its precise biochemical function remains under investigation, research suggests that Hematological and neurological expressed 1 may act as a scaffolding or regulatory protein influencing cytoskeletal organization and signal transduction. HN1 antibody provides an important reagent for characterizing this protein's role in normal physiology and disease contexts, particularly in hematopoietic and neurological systems where it is strongly expressed.

Studies have shown that Hematological and neurological expressed 1 participates in proliferation and survival pathways, potentially through interaction with kinases and growth factor receptors. Detection with HN1 antibody has revealed changes in expression during cell cycle progression and differentiation, supporting the idea that this protein integrates extracellular signals with cellular responses. In hematopoietic cells, HN1 may regulate developmental transitions, while in the nervous system, it is linked to neuronal outgrowth and plasticity. Its broad expression pattern suggests that HN1 contributes to multiple cellular functions beyond its namesake tissues.

In cancer research, HN1 has drawn attention as a marker of poor prognosis in several malignancies. Elevated levels have been reported in breast, lung, and liver cancers, where it correlates with increased proliferation and invasiveness. Research using HN1 antibody has demonstrated that silencing or overexpression of HN1 alters tumor cell behavior, implicating it in oncogenic pathways. Because of its association with tumor growth and survival, Hematological and neurological expressed 1 is being investigated as a potential biomarker and therapeutic target.

HN1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting identifies expression changes under experimental conditions such as growth factor stimulation. Immunohistochemistry demonstrates tissue and tumor specific localization, while immunofluorescence reveals cytoplasmic and nuclear distribution. These applications make HN1 antibody versatile for investigating fundamental biology and translational cancer research.

By supplying validated HN1 antibody reagents, NSJ Bioreagents supports discovery of the functions of Hematological and neurological expressed 1, ensuring that researchers can explore its role in cell signaling, differentiation, and disease progression.

UniProt: Q9UK76