HSD17B2 anticorps

N° du produit ABIN7881141

L’anticorps anti-HSD17B2 Polyclonal Lapin est utilisé pour la détection de HSD17B2 dans des échantillons de Humain. Il a été validé pour WB et FACS.

Aperçu rapide pour HSD17B2 anticorps (ABIN7881141)

Antigène: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD17B2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-HSD17B2 anticorps

Fonction: HSD17B2 Antibody

Séquence: IYDYFAKRHF GQDK

Purification: Affinity purified

Immunogène: Amino acids IYDYFAKRHFGQDK from the human protein were used as the immunogen for the HSD17B2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the HSD17B2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the HSD17B2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur HSD17B2

Antigène: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Autre désignation: HSD17B2

Sujet: HSD17B2 (17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42 (43 % ) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.

UniProt: P37059

Pathways: Steroid Hormone Biosynthesis