Recombinant INMT anticorps

N° du produit ABIN7881168

L’anticorps anti-INMT Monoclonal Lapin est utilisé pour la détection de INMT dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB.

Aperçu rapide pour Recombinant INMT anticorps (ABIN7881168)

Antigène: INMT (Indolethylamine N-Methyltransferase (INMT))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp INMT est non-conjugé

Application: Western Blotting (WB)

Clone: 29I89

Détail du produit anti-INMT anticorps

Fonction: INMT Antibody / TEMT

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human TEMT was used as the immunogen for the INMT antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the INMT antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the INMT antibody at -20oC.

Détails sur INMT

Antigène: INMT (Indolethylamine N-Methyltransferase (INMT))

Autre désignation: INMT

Sujet: INMT antibody detects indolethylamine N methyltransferase, also known as TEMT, encoded by the INMT gene. INMT is a cytosolic enzyme that catalyzes the N methylation of tryptamine and other indolethylamines, producing N N dimethyltryptamine and related metabolites. This activity places INMT in pathways regulating biogenic amine metabolism, neurotransmitter balance, and endogenous hallucinogen production. INMT is expressed in liver, lung, brain, and peripheral tissues, suggesting roles in both metabolic clearance and neuroregulation.

INMT antibody is widely applied in neurobiology, pharmacology, and metabolism research. INMT contributes to serotonin and tryptamine metabolism and has been proposed as the enzyme responsible for biosynthesis of endogenous dimethyltryptamine in mammals. By detecting INMT, researchers can examine its distribution, activity, and regulation in diverse tissues.

Western blotting with INMT antibody detects enzyme expression in liver and brain samples. Immunohistochemistry maps expression in neuronal and peripheral tissues, while immunofluorescence highlights cytoplasmic localization within cells. These approaches provide powerful tools for characterizing INMT biology.

INMT has clinical and pharmacological significance. Altered expression has been linked to pulmonary hypertension, schizophrenia, and other neuropsychiatric conditions. Genetic polymorphisms in INMT influence enzyme activity and metabolic profiles. By applying INMT antibody, scientists can explore how changes in tryptamine metabolism contribute to disease and therapeutic response.

INMT also participates in xenobiotic metabolism by methylating exogenous compounds. Its role in detoxification pathways expands its relevance to pharmacology and toxicology. INMT antibody supports studies into how methyltransferases regulate chemical balance in the body.

Research continues to evaluate INMT in neurological function, where dimethyltryptamine has been implicated in altered states of consciousness and potential therapeutic applications. Investigating INMT expression with antibody based methods provides insights into both fundamental biology and emerging areas of translational research.

INMT antibody from NSJ Bioreagents provides reliable specificity for detecting indolethylamine N methyltransferase. Its performance across assays ensures accurate results in metabolism, neuroscience, and pharmacology.

UniProt: O95050