Recombinant IL18BP anticorps

N° du produit ABIN7881287

Cet anticorps anti-IL18BP Monoclonal Lapin (Clone 31I00) (ABIN7881287) détecte spécifiquement IL18BP dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour Recombinant IL18BP anticorps (ABIN7881287)

Antigène: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp IL18BP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 31I00

Détail du produit anti-IL18BP anticorps

Fonction: IL18BP Antibody / IL18 binding protein

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human IL18 binding protein was used as the immunogen for the IL18BP antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the IL18BP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the IL18BP antibody at -20oC.

Détails sur IL18BP

Antigène: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Autre désignation: IL18BP

Sujet: IL18BP antibody detects interleukin 18 binding protein, encoded by the IL18BP gene. This secreted glycoprotein functions as a natural inhibitor of interleukin 18, a proinflammatory cytokine. Alternate names include IL18BPa, IL18BPb, and IL18BPc, reflecting the multiple isoforms generated by alternative splicing. IL18BP neutralizes IL18 by binding with high affinity, preventing its interaction with the IL18 receptor and subsequent activation of NF kappa B and interferon gamma pathways.

IL18BP antibody is widely applied in immunology, inflammation research, and translational medicine. By detecting IL18BP, researchers can investigate how immune regulation balances inflammatory cytokine activity. Overexpression of IL18BP provides protection from excessive inflammation, while deficiency or altered expression contributes to autoimmune disorders and infectious disease susceptibility.

ELISA detects IL18BP in serum and culture supernatants, while western blotting identifies isoform expression. Immunohistochemistry maps IL18BP production in tissues undergoing immune activation. These methods make IL18BP antibody useful for evaluating cytokine regulation in health and disease.

IL18BP has therapeutic potential as a biologic agent. Recombinant IL18BP has been developed to treat inflammatory diseases such as adult onset Still disease and hemophagocytic lymphohistiocytosis. By applying IL18BP antibody, researchers can monitor therapeutic levels and investigate how modulation of IL18 signaling influences disease outcomes.

IL18BP antibody from NSJ Bioreagents delivers dependable specificity for analyzing interleukin 18 binding protein. Its reliable performance across assays ensures accurate detection of this immune regulator.

UniProt: O95998