LRP1 anticorps

N° du produit ABIN7881484

L’anticorps anti-LRP1 Monoclonal Souris est utilisé pour la détection de LRP1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour LRP1 anticorps (ABIN7881484)

Antigène: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LRP1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: LRP1-6784

Détail du produit anti-LRP1 anticorps

Fonction: Alpha 2 macroglobulin receptor Antibody / CD91 / LRP1

Purification: Protein A/G affinity

Immunogène: A recombinant fragment of human protein was used as the immunogen for the Alpha 2 macroglobulin receptor antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Alpha 2 macroglobulin receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Alpha 2 macroglobulin receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur LRP1

Antigène: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Autre désignation: Alpha 2 macroglobulin receptor

Sujet: Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and Alpha-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including Alpha-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.

UniProt: Q07954

Pathways: Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling