Recombinant MVP anticorps

N° du produit ABIN7881540

Cet anticorps Souris Monoclonal détecte spécifiquement MVP dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant MVP anticorps (ABIN7881540)

Antigène: MVP (Major Vault Protein (MVP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MVP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: R1032

Détail du produit anti-MVP anticorps

Fonction: Recombinant MVP Antibody / Major Vault Protein (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Proteins precipitated from human breast cancer MCF-7 cells were used as the immunogen for the recombinant MVP antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant MVP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant MVP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MVP

Antigène: MVP (Major Vault Protein (MVP))

Autre désignation: MVP

Sujet: Recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70 % of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

UniProt: Q14764