MBD1 anticorps

N° du produit ABIN7881625

L’anticorps anti-MBD1 Monoclonal Souris est utilisé pour la détection de MBD1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour MBD1 anticorps (ABIN7881625)

Antigène: MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MBD1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: CPTC-MBD1-1

Détail du produit anti-MBD1 anticorps

Fonction: MBD1 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Recombinant human protein was used as the immunogen for the MBD1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the MBD1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the MBD1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MBD1

Antigène: MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))

Autre désignation: MBD1

Sujet: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. MBD1 has also been predicted to be involved in the development and progression of tumors, and it has been shown that MBD1 is significantly upregulated in pancreatic cancer tissues when compared with surrounding normal tissues. Furthermore, MBD1 may serve as a potential therapeutic target for pancreatic cancer.

UniProt: Q9UIS9