MBD1 anticorps

N° du produit ABIN7881626

Cet anticorps anti-MBD1 Monoclonal Souris (Clone CPTC-MBD1-1) (ABIN7881626) détecte spécifiquement MBD1 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MBD1 anticorps (ABIN7881626)

Antigène: MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MBD1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CPTC-MBD1-1

Détail du produit anti-MBD1 anticorps

Fonction: MBD1 Antibody

Purification: Protein G affinity chromatography

Immunogène: Recombinant human protein was used as the immunogen for the MBD1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the MBD1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the MBD1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MBD1

Antigène: MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))

Autre désignation: MBD1

Sujet: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. MBD1 has also been predicted to be involved in the development and progression of tumors, and it has been shown that MBD1 is significantly upregulated in pancreatic cancer tissues when compared with surrounding normal tissues. Furthermore, MBD1 may serve as a potential therapeutic target for pancreatic cancer.

UniProt: Q9UIS9