Netrin 4 anticorps

N° du produit ABIN7881782

Cet anticorps anti-Netrin 4 Polyclonal Lapin (ABIN7881782) détecte spécifiquement Netrin 4 dans WB, IHC et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Netrin 4 anticorps (ABIN7881782)

Antigène: Netrin 4 (NTN4)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Netrin 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-Netrin 4 anticorps

Fonction: NTN4 Antibody / Netrin 4

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human NTN4 recombinant protein (Position: C?) was used as the immunogen for the NTN4 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NTN4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the NTN4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Netrin 4

Antigène: Netrin 4 (NTN4)

Autre désignation: NTN4

Sujet: NTN4 antibody detects Netrin-4, a secreted extracellular matrix protein that guides axonal growth, angiogenesis, and tissue morphogenesis. The UniProt recommended name is Netrin-4 (NTN4). This laminin-related guidance molecule plays a dual role in promoting or inhibiting cell migration and adhesion depending on receptor context and tissue environment.

Functionally, NTN4 antibody identifies a 628-amino-acid protein secreted into the extracellular space, where it binds to receptors such as UNC5B, DCC, and integrins. NTN4 regulates neuronal guidance during development by controlling axonal attraction and repulsion. Beyond the nervous system, NTN4 influences angiogenesis by modulating endothelial cell proliferation and migration, acting as both a pro- and anti-angiogenic factor in different contexts. NTN4 also contributes to basement membrane organization and vascular permeability regulation.

The NTN4 gene is located on chromosome 12q22 and is expressed in brain, lung, kidney, and vascular tissues. Expression is upregulated during embryonic development, tissue regeneration, and pathological angiogenesis. NTN4 is also found in the extracellular matrix of epithelial and endothelial cells, where it interacts with laminins and collagen IV to maintain structural stability.

Pathologically, altered NTN4 expression is associated with cancer, diabetic retinopathy, and neurodevelopmental disorders. Overexpression can promote tumor growth and angiogenesis, while loss of function leads to impaired vessel formation and axonal misguidance. NTN4 acts as a context-dependent regulator of cellular adhesion, guiding both neural and vascular remodeling. Research using NTN4 antibody supports studies in extracellular matrix biology, neurodevelopment, and angiogenesis.

NTN4 antibody is validated for western blotting, immunohistochemistry, and ELISA to detect secreted matrix proteins. NSJ Bioreagents provides NTN4 antibody reagents optimized for research in neural guidance, vascular development, and extracellular matrix signaling.

Structurally, Netrin-4 consists of a laminin N-terminal domain (LN), three laminin-type epidermal growth factor-like repeats (LE), and a C-terminal NTR domain that mediates receptor interactions. This modular organization enables NTN4 to function as both a structural matrix component and a signaling ligand. This antibody facilitates research into NTN4's roles in neural patterning, angiogenesis, and tumor microenvironment regulation.

UniProt: Q9HB63