Recombinant NUP155 anticorps

N° du produit ABIN7881861

Cet anticorps Lapin Monoclonal détecte spécifiquement NUP155 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant NUP155 anticorps (ABIN7881861)

Antigène: NUP155 (Nucleoporin 155kDa (NUP155))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp NUP155 est non-conjugé

Application: Western Blotting (WB)

Clone: 30N56

Détail du produit anti-NUP155 anticorps

Fonction: NUP155 Antibody / Nucleoporin 155

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human NUP155 was used as the immunogen for the NUP155 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NUP155 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the NUP155 antibody at -20oC.

Détails sur NUP155

Antigène: NUP155 (Nucleoporin 155kDa (NUP155))

Autre désignation: NUP155

Sujet: NUP155 antibody recognizes nucleoporin 155, a major component of the nuclear pore complex encoded by the NUP155 gene. Nuclear pore complexes are large protein assemblies embedded in the nuclear envelope that regulate transport of molecules between the nucleus and cytoplasm. NUP155 contributes to the structural integrity of the pore and facilitates trafficking of RNAs, proteins, and signaling molecules.

NUP155 antibody is commonly used in studies of nucleocytoplasmic transport and nuclear architecture. The protein is particularly important for maintaining nuclear envelope stability and selective transport of cargo. Defects in NUP155 impair nuclear pore complex assembly and disrupt gene regulation by altering nucleo cytoplasmic communication.

The antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, NUP155 antibody recognizes protein bands corresponding to the expected molecular weight. Immunohistochemistry shows localization at the nuclear envelope, while immunofluorescence provides fine resolution of subnuclear distribution. These applications make NUP155 antibody versatile for research in molecular biology and cell signaling.

Clinical research has linked NUP155 mutations to atrial fibrillation and sudden cardiac death. The connection underscores the importance of nuclear pore complexes beyond basic transport, showing that nuclear envelope proteins contribute to cardiac rhythm and function. By detecting NUP155, researchers can explore how mutations or altered expression influence disease progression.

Nucleoporins, including NUP155, are increasingly recognized as regulators of gene expression. Their roles extend to chromatin organization, DNA repair, and signal transduction. Dysregulation of nucleoporins has been linked to cancer and developmental disorders. NUP155 antibody provides a tool to investigate how nuclear pore function impacts diverse biological processes.

NUP155 antibody from NSJ Bioreagents provides reliable specificity for analyzing nuclear pore biology, disease pathogenesis, and cellular communication. It is a valuable reagent for laboratories studying nuclear transport and gene regulation.

UniProt: O75694

Pathways: Protein targeting to Nucleus