Recombinant PMF1 anticorps

N° du produit ABIN7881994

L’anticorps anti-PMF1 Monoclonal Lapin est utilisé pour la détection de PMF1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et IP.

Aperçu rapide pour Recombinant PMF1 anticorps (ABIN7881994)

Antigène: PMF1 (Polyamine Modulated Factor 1 (PMF1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PMF1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: 30P63

Détail du produit anti-PMF1 anticorps

Fonction: PMF1 Antibody / Polyamine modulated factor 1

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human PMF1 was used as the immunogen for the PMF1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PMF1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the PMF1 antibody at -20oC.

Détails sur PMF1

Antigène: PMF1 (Polyamine Modulated Factor 1 (PMF1))

Autre désignation: PMF1

Sujet: PMF1 antibody detects Polyamine modulated factor 1, encoded by the PMF1 gene. Polyamine modulated factor 1 is a nuclear protein that functions as a transcriptional cofactor, particularly in regulating the activity of the transcription factor Nrf2 and the antioxidant response element pathway. PMF1 antibody provides researchers with a critical reagent to study oxidative stress, transcriptional regulation, and cancer biology.

Polyamine modulated factor 1 was originally identified for its ability to influence the binding of transcription factors to DNA in the presence of polyamines. Research using PMF1 antibody has demonstrated that it plays an essential role in regulating gene expression by modulating Nrf2 activity and controlling antioxidant response elements. This pathway is central to cellular defense against oxidative damage and environmental stressors, and PMF1 activity is critical in fine-tuning this response.

Beyond its role in transcription, PMF1 has been associated with chromatin organization. Studies with PMF1 antibody have shown that it interacts with histone modifying enzymes, suggesting a role in epigenetic regulation. By influencing both transcription factors and chromatin state, Polyamine modulated factor 1 integrates multiple layers of gene expression control. These findings expand its importance beyond a cofactor to a regulator of genome activity.

PMF1 has also been implicated in cancer. Research using PMF1 antibody has revealed altered expression in several tumor types, including lung, colon, and liver cancers. Elevated levels of PMF1 may enhance antioxidant defenses in tumor cells, promoting survival under stress conditions. Conversely, reduced expression may impair cellular responses to oxidative injury. These dual roles highlight its potential as a biomarker and therapeutic target.

PMF1 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects endogenous protein levels, immunohistochemistry highlights nuclear localization in tissue samples, and immunofluorescence demonstrates dynamic changes after oxidative stress. These applications make PMF1 antibody indispensable for transcription and stress research.

By supplying validated PMF1 antibody reagents, NSJ Bioreagents supports research into transcriptional regulation, oxidative stress, and cancer. Detection of Polyamine modulated factor 1 provides insight into how nuclear cofactors integrate environmental signals and gene expression.

UniProt: Q6P1K2