PKD1 anticorps

N° du produit ABIN7881995

Cet anticorps anti-PKD1 Polyclonal Chèvre (ABIN7881995) détecte spécifiquement PKD1 dans ELISA et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PKD1 anticorps (ABIN7881995)

Antigène: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PKD1 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PKD1 anticorps

Fonction: Polycystin 1 Antibody / PKD1

Séquence: RTPLRAKNKV HP

Purification: Antigen affinity

Immunogène: Amino acids RTPLRAKNKVHP were used as the immunogen for this Polycystin 1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Polycystin 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: 0.5 mg/mL in 1X TBS, pH 7.3, with 0.5 % BSA (US sourced) and 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot and store the Polycystin 1 antibody at -20oC.

Détails sur PKD1

Antigène: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Autre désignation: Polycystin 1

Sujet: Polycystin 1, also known as PKD1, is a protein encoded by the PKD1 gene and is crucial in the development of Polycystic Kidney Disease (PKD). PKD1 mutations are responsible for the majority of cases of autosomal dominant PKD, a genetic disorder that causes the formation of fluid-filled cysts in the kidneys. Polycystin 1 is a transmembrane protein that plays a vital role in cell-cell and cell-matrix interactions. It is primarily expressed in the kidneys, liver, pancreas, and other tissues, where it helps regulate cell proliferation, differentiation, and apoptosis. Dysfunction of Polycystin 1 disrupts these essential cellular processes, leading to the formation of cysts in the kidneys. Research has shown that Polycystin 1 interacts with other proteins, such as Polycystin 2, to form a protein complex that regulates calcium signaling and cell growth. Mutations in PKD1 disrupt this complex, causing aberrant calcium signaling and uncontrolled cell proliferation, which ultimately results in cyst formation and kidney damage. Studies have also suggested that Polycystin 1 may play a role in the mechanosensory function of kidney epithelial cells, allowing them to respond to changes in fluid flow and pressure within the nephron. Dysregulation of this mechanosensory function due to PKD1 mutations may contribute to the development and progression of PKD.

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location