Recombinant PDIA4 anticorps

N° du produit ABIN7882074

Cet anticorps Lapin Monoclonal détecte spécifiquement PDIA4 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant PDIA4 anticorps (ABIN7882074)

Antigène: PDIA4 (Protein Disulfide Isomerase Family A, Member 4 (PDIA4))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PDIA4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 32P79

Détail du produit anti-PDIA4 anticorps

Fonction: PDIA4 Antibody / Protein disulfide-isomerase A4 / ERp72

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human ERp72 was used as the immunogen for the PDIA4 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PDIA4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the PDIA4 antibody at -20oC.

Détails sur PDIA4

Antigène: PDIA4 (Protein Disulfide Isomerase Family A, Member 4 (PDIA4))

Autre désignation: PDIA4

Sujet: PDIA4 antibody detects Protein disulfide-isomerase A4, also known as ERp72, encoded by the PDIA4 gene. Protein disulfide-isomerase A4 is an endoplasmic reticulum resident enzyme that catalyzes the formation, isomerization, and reduction of disulfide bonds in nascent proteins. PDIA4 antibody provides researchers with a robust reagent to study protein folding, quality control, and endoplasmic reticulum function.

Protein disulfide-isomerase A4 is a member of the protein disulfide-isomerase family, characterized by thioredoxin-like domains that mediate redox reactions. Research using PDIA4 antibody has shown that ERp72 interacts with a wide range of substrates, ensuring correct disulfide bond formation during protein maturation. This activity contributes to protein stability and function, making PDIA4 essential for secretory pathway homeostasis.

PDIA4 also plays a role in the unfolded protein response. Studies with PDIA4 antibody have demonstrated that its expression increases during endoplasmic reticulum stress, reflecting a need for enhanced protein folding capacity. By assisting in protein quality control, PDIA4 protects cells from accumulation of misfolded proteins and prevents activation of apoptosis pathways triggered by unresolved stress.

Beyond folding, Protein disulfide-isomerase A4 has been linked to calcium homeostasis and chaperone activity. Research using PDIA4 antibody has suggested that ERp72 participates in calcium binding and contributes to regulation of calcium dependent processes in the endoplasmic reticulum. These functions underscore the multifunctional nature of PDIA4 in cellular physiology.

Dysregulation of PDIA4 is associated with disease. Elevated expression has been observed in cancers, where increased folding capacity supports tumor cell survival under stress. Conversely, mutations or impaired function may contribute to protein misfolding disorders. Research using PDIA4 antibody has revealed roles in neurodegeneration, diabetes, and cardiovascular disease, reflecting its broad importance across pathologies.

PDIA4 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects ER localized PDIA4, immunohistochemistry highlights expression in secretory tissues, and immunofluorescence reveals endoplasmic reticulum distribution. These applications make PDIA4 antibody a valuable tool in cell biology and disease research.

By supplying validated PDIA4 antibody reagents, NSJ Bioreagents supports research into protein folding, quality control, and disease mechanisms. Detection of Protein disulfide-isomerase A4 provides insight into how protein maturation in the endoplasmic reticulum influences cellular health.

UniProt: P13667

Pathways: Thyroid Hormone Synthesis, Cell RedoxHomeostasis