Recombinant RAPGEF4 anticorps

N° du produit ABIN7882136

Cet anticorps anti-RAPGEF4 Monoclonal Lapin (Clone 22R17) (ABIN7882136) détecte spécifiquement RAPGEF4 dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant RAPGEF4 anticorps (ABIN7882136)

Antigène: RAPGEF4 (Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp RAPGEF4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 22R17

Détail du produit anti-RAPGEF4 anticorps

Fonction: RAPGEF4 Antibody / EPAC 2

Purification: Affinity chromatography

Immunogène: A peptide sequence specific to Rap guanine nucleotide exchange factor 4 protein was used as the immunogen for the RAPGEF4 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the RAPGEF4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the RAPGEF4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur RAPGEF4

Antigène: RAPGEF4 (Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))

Autre désignation: RAPGEF4

Sujet: Rap guanine nucleotide exchange factor 4 (RAPGEF4), also known as EPAC 2 (Exchange protein directly activated by cAMP 2), is a cAMP-regulated guanine nucleotide exchange factor that activates Rap1 and Rap2 small GTPases. Unlike protein kinase A, RAPGEF4 mediates cAMP signaling through a PKA-independent pathway, influencing processes such as cell adhesion, insulin secretion, and synaptic plasticity.

RAPGEF4 is expressed predominantly in the brain and endocrine tissues, where it contributes to learning and memory, hormone release, and neuronal signaling. Altered RAPGEF4 function has been implicated in metabolic disorders, neuropsychiatric conditions, and cancer, making it a significant target for biomedical research.

Using a high-quality RAPGEF4 antibody allows for sensitive detection in applications such as western blot, immunohistochemistry, and immunofluorescence. A RAPGEF4 antibody from NSJ Bioreagents ensures reliable and reproducible performance for studies in cAMP signaling, neuronal function, and endocrine regulation. Selecting the right RAPGEF4 antibody is essential for achieving accurate and consistent experimental results.

UniProt: Q8WZA2

Pathways: Hormone Transport, Smooth Muscle Cell Migration