SLC9A3 anticorps

N° du produit ABIN7882330

L’anticorps anti-SLC9A3 Polyclonal Lapin est utilisé pour la détection de SLC9A3 dans des échantillons de Humain et Souris. Il a été validé pour WB, ELISA, IHC et IP.

Aperçu rapide pour SLC9A3 anticorps (ABIN7882330)

Antigène: SLC9A3 (Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC9A3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-SLC9A3 anticorps

Fonction: SLC9A3 Antibody / Sodium/hydrogen exchanger 3

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human SLC9A3 recombinant protein (Position: 667-831) was used as the immunogen for the SLC9A3 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SLC9A3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SLC9A3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SLC9A3

Antigène: SLC9A3 (Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3))

Autre désignation: SLC9A3

Sujet: SLC9A3 antibody detects Sodium/hydrogen exchanger 3, a membrane transporter that regulates intracellular pH and sodium absorption in epithelial tissues. SLC9A3 plays a vital role in electrolyte balance, acid-base homeostasis, and fluid reabsorption in the kidney and intestine. The SLC9A3 antibody is widely used in renal physiology, gastrointestinal, and cell signaling research to study ion transport mechanisms and epithelial function.

SLC9A3 is encoded by the SLC9A3 gene located on human chromosome 5p15.33. The protein is approximately 834 amino acids long and belongs to the solute carrier 9 family of sodium/hydrogen exchangers (NHEs). It is predominantly expressed in the apical membrane of renal proximal tubule and intestinal epithelial cells, where it exchanges intracellular hydrogen ions for extracellular sodium ions, helping to regulate pH and volume.

The SLC9A3 antibody detects a 90 kilodalton band by western blot and shows apical membrane staining in epithelial tissues under immunofluorescence microscopy. Through its role in sodium absorption, SLC9A3 contributes to systemic blood pressure control and fluid balance. Regulation of SLC9A3 activity is mediated by phosphorylation and interaction with scaffold proteins such as NHERF1 and ezrin, linking it to hormonal control by angiotensin II and parathyroid hormone.

Mutations in SLC9A3 cause congenital secretory diarrhea and male infertility due to defective sodium transport and fluid absorption. In the kidney, SLC9A3 dysfunction results in impaired bicarbonate reabsorption and metabolic acidosis. Its regulation is critical for maintaining acid-base equilibrium, and its altered expression has been linked to cystic fibrosis and inflammatory bowel disease.

As an essential component of epithelial ion transport, SLC9A3 integrates metabolic, hormonal, and mechanical stimuli to maintain homeostasis. NSJ Bioreagents provides a validated SLC9A3 antibody optimized for its applications, supporting research into renal physiology, intestinal absorption, and electrolyte balance.

UniProt: P48764

Pathways: Proton Transport