Recombinant Sorting Nexin 4 anticorps

N° du produit ABIN7882338

Cet anticorps Lapin Monoclonal détecte spécifiquement Sorting Nexin 4 dans WB et IP. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant Sorting Nexin 4 anticorps (ABIN7882338)

Antigène: Sorting Nexin 4 (SNX4)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Sorting Nexin 4 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: 30S54

Détail du produit anti-Sorting Nexin 4 anticorps

Fonction: SNX4 Antibody / Sorting nexin 4

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human SNX4 was used as the immunogen for the SNX4 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SNX4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the SNX4 antibody at -20oC.

Détails sur Sorting Nexin 4

Antigène: Sorting Nexin 4 (SNX4)

Autre désignation: SNX4

Sujet: SNX4 antibody detects sorting nexin 4, a member of the sorting nexin family encoded by the SNX4 gene. Sorting nexins are characterized by the presence of a phox homology domain that binds phosphoinositides, enabling association with endosomal membranes. SNX4 is primarily involved in endosomal trafficking, cargo sorting, and membrane remodeling. By directing proteins to recycling or degradative pathways, SNX4 maintains cellular homeostasis and regulates receptor signaling.

SNX4 antibody is widely applied in studies of membrane trafficking, endocytosis, and signal transduction. Sorting nexin 4 is part of the retromer independent recycling pathway and contributes to the trafficking of proteins such as the transferrin receptor. Disruption of SNX4 function impairs endosomal sorting and alters nutrient uptake, receptor turnover, and intracellular signaling dynamics. By detecting SNX4, researchers can explore how sorting nexins control endosomal recycling and cell surface composition.

In western blot assays, SNX4 antibody detects protein bands of the expected size in cell and tissue extracts. Immunohistochemistry highlights expression in epithelial and neuronal tissues, while immunofluorescence maps SNX4 distribution on endosomal membranes. These methods support detailed analysis of endosomal dynamics.

SNX4 has been implicated in neurodegenerative disease and cancer. Altered expression affects autophagy, mitochondrial function, and neuronal survival. In oncology, abnormal SNX4 activity influences growth factor receptor trafficking and signaling, potentially affecting tumor progression. By applying SNX4 antibody, scientists can investigate how sorting nexin mediated trafficking pathways contribute to both normal physiology and disease.

SNX4 antibody from NSJ Bioreagents provides dependable specificity for exploring membrane trafficking and signaling. Its versatility across assays makes it an essential reagent for cell biology and disease related research.

UniProt: O95219