Recombinant SNX5 anticorps

N° du produit ABIN7882339

L’anticorps anti-SNX5 Monoclonal Lapin est utilisé pour la détection de SNX5 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC, IF et ICC.

Aperçu rapide pour Recombinant SNX5 anticorps (ABIN7882339)

Antigène: SNX5 (Sorting Nexin 5 (SNX5))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SNX5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 30S11

Détail du produit anti-SNX5 anticorps

Fonction: SNX5 Antibody / Sorting nexin 5

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human SNX5 was used as the immunogen for the SNX5 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SNX5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the SNX5 antibody at -20oC.

Détails sur SNX5

Antigène: SNX5 (Sorting Nexin 5 (SNX5))

Autre désignation: SNX5

Sujet: SNX5 antibody detects sorting nexin 5, a member of the sorting nexin family that regulates endosomal trafficking and membrane remodeling. SNX5 contains a phox homology (PX) domain, which binds phosphoinositides on endosomal membranes, and a BAR domain, which promotes membrane curvature and tubulation. Together, these domains allow SNX5 to coordinate cargo retrieval from endosomes and direct proteins to specific intracellular destinations.

Research using SNX5 antibody has shown that SNX5 participates in the retromer complex, where it cooperates with other sorting nexins such as SNX1 and SNX2 to mediate retrograde transport of receptors and enzymes. Disruption of SNX5 function impairs recycling of critical cargo such as cation-independent mannose-6-phosphate receptors, affecting lysosomal enzyme trafficking. These defects can contribute to lysosomal storage disorders and cellular stress responses.

SNX5 has also been linked to viral infection and cancer biology. Certain viruses exploit SNX5-mediated endosomal pathways to promote entry and replication, while altered expression of SNX5 in cancer may influence cell signaling, proliferation, and migration. Its role in trafficking growth factor receptors underscores its significance in tumor biology. In immune cells, SNX5 contributes to antigen presentation by regulating transport of major histocompatibility complex molecules.

Antibodies against SNX5 are validated for western blot, immunohistochemistry, and immunofluorescence. These tools enable analysis of protein expression, intracellular localization, and retromer function. Clone-based antibodies ensure specificity, distinguishing SNX5 from other sorting nexins with overlapping roles.

NSJ Bioreagents provides this SNX5 antibody to support studies in endosomal trafficking, retromer biology, and disease pathways.

UniProt: Q9Y5X3