Recombinant TARDBP anticorps

N° du produit ABIN7882427

Cet anticorps anti-TARDBP Monoclonal Lapin (Clone 26T75) (ABIN7882427) détecte spécifiquement TARDBP dans WB, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant TARDBP anticorps (ABIN7882427)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 26T75

Détail du produit anti-TARDBP anticorps

Fonction: TAR DNA binding protein 43 Antibody / TDP43 / TARDBP

Purification: Affinity chromatography

Immunogène: A peptide sequence specific to TAR DNA binding protein 43 was used as the immunogen for the TAR DNA binding protein 43 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TAR DNA binding protein 43 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TAR DNA binding protein 43 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TAR DNA binding protein 43

Sujet: TAR DNA binding protein 43 is a DNA/RNA-binding protein that shuttles between nucleus and cytoplasm to coordinate RNA metabolism. It recognizes UG-rich sequences via 2 RNA recognition motifs and uses a glycine-rich C-terminus to assemble ribonucleoprotein complexes. TAR DNA binding protein 43 regulates alternative splicing, transcript stability, 3' end processing, and mRNA transport, integrating these steps with transcription-coupled RNA handling across diverse cell types.

It participates in stress-responsive RNA granule dynamics and controlled phase behavior, linking RNA sorting to protein quality control pathways. Its nuclear enrichment, regulated export, and post-translational modification states offer quantitative readouts for studies of RNA processing, trafficking, and cellular adaptation in defined model systems.

The TAR DNA binding protein 43 antibody from NSJ Bioreagents enables specific detection of endogenous TDP-43 in applications such as western blot, immunofluorescence, immunohistochemistry, immunoprecipitation, and RNA-protein pulldown workflows. Researchers use the TAR DNA binding protein 43 antibody to measure total protein levels, assess nuclear-cytoplasmic distribution, and evaluate biochemical fractionation or stress-induced relocalization when paired with appropriate complementary reagents. With high specificity and reproducible performance, the TAR DNA binding protein 43 antibody supports rigorous analysis of RNA-binding protein networks and post-transcriptional regulation.

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion