Recombinant TIMM44 anticorps

N° du produit ABIN7882540

L’anticorps anti-TIMM44 Monoclonal Lapin est utilisé pour la détection de TIMM44 dans des échantillons de Humain et Rat. Il a été validé pour WB, IF, ICC, IP et FACS.

Aperçu rapide pour Recombinant TIMM44 anticorps (ABIN7882540)

Antigène: TIMM44 (Translocase of Inner Mitochondrial Membrane 44 (TIMM44))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TIMM44 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FACS)

Clone: 30T70

Détail du produit anti-TIMM44 anticorps

Fonction: TIMM44 Antibody / Translocase of inner mitochondrial membrane 44

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human TIM44 was used as the immunogen for the TIMM44 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TIMM44 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the TIMM44 antibody at -20oC.

Détails sur TIMM44

Antigène: TIMM44 (Translocase of Inner Mitochondrial Membrane 44 (TIMM44))

Autre désignation: TIMM44

Sujet: TIM44 antibody recognizes translocase of inner mitochondrial membrane 44, a central component of the mitochondrial protein import machinery. TIM44 anchors mitochondrial Hsp70 to the inner membrane, enabling preprotein translocation through the TIM23 complex. By facilitating proper protein targeting, TIM44 ensures mitochondrial biogenesis and maintenance of energy production.

Research using TIM44 antibody has highlighted its importance in mitochondrial function and human disease. Altered expression of TIM44 can impair protein import, leading to mitochondrial stress and metabolic dysfunction. Dysregulation has been linked to neurodegenerative conditions, where defective energy metabolism is a hallmark, and to metabolic syndromes associated with impaired mitochondrial quality control.

Validated clones for TIM44 detection are suitable for western blot, immunofluorescence, and immunohistochemistry. These reagents allow investigators to track mitochondrial protein import efficiency and examine changes in response to cellular stress. Monitoring TIM44 levels provides valuable insight into how cells adapt to demands on mitochondrial biogenesis and oxidative metabolism.

NSJ Bioreagents offers this TIM44 antibody to support studies in mitochondrial biology, metabolic regulation, and disease. Alternate names include translocase of inner mitochondrial membrane 44 antibody, mitochondrial import receptor subunit TIM44 antibody, and HSP-binding protein antibody.

UniProt: O43615