Recombinant TMEM67 anticorps

N° du produit ABIN7882553

Cet anticorps anti-TMEM67 Monoclonal Lapin (Clone 30T77) (ABIN7882553) détecte spécifiquement TMEM67 dans WB, IF, IHC, FACS et ICC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant TMEM67 anticorps (ABIN7882553)

Antigène: TMEM67 (Transmembrane Protein 67 (TMEM67))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TMEM67 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 30T77

Détail du produit anti-TMEM67 anticorps

Fonction: TMEM67 Antibody / Meckelin

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human Meckelin was used as the immunogen for the TMEM67 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TMEM67 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the TMEM67 antibody at -20oC.

Détails sur TMEM67

Antigène: TMEM67 (Transmembrane Protein 67 (TMEM67))

Autre désignation: TMEM67

Sujet: TMEM67 antibody detects meckelin, a transmembrane protein encoded by the TMEM67 gene. Meckelin localizes to primary cilia and the plasma membrane, where it contributes to ciliary structure and signaling. Mutations in TMEM67 cause Meckel syndrome type 3 and Joubert syndrome type 6, autosomal recessive ciliopathies characterized by developmental abnormalities, cystic kidneys, and neurological defects. Meckelin is therefore essential for cilia based signaling pathways, including Wnt and Hedgehog.

TMEM67 antibody is widely applied in developmental biology, nephrology, and neurogenetics. By detecting meckelin, researchers can study how ciliary proteins regulate organ development and signaling. Ciliary dysfunction underlies a spectrum of disorders known as ciliopathies, linking TMEM67 research to human disease mechanisms.

Western blot assays detect meckelin in tissue lysates, while immunohistochemistry maps expression in kidney, brain, and liver. Immunofluorescence highlights punctate staining at primary cilia, consistent with its functional localization. These applications provide robust tools for examining ciliary protein biology.

Meckelin plays roles in regulating planar cell polarity, neuronal migration, and renal morphogenesis. Its dysfunction disrupts signaling and tissue organization, causing developmental defects and organ pathology. By applying TMEM67 antibody, scientists can investigate pathways linking ciliary function to embryogenesis, neurodevelopment, and kidney disease.

TMEM67 antibody from NSJ Bioreagents delivers dependable specificity for studying meckelin function. Its strong performance ensures accurate detection across developmental and disease contexts.

UniProt: Q5HYA8