Recombinant UBA7 anticorps

N° du produit ABIN7882633

L’anticorps anti-UBA7 Monoclonal Lapin est utilisé pour la détection de UBA7 dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, IHC et FACS.

Aperçu rapide pour Recombinant UBA7 anticorps (ABIN7882633)

Antigène: UBA7 (Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp UBA7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 31U08

Détail du produit anti-UBA7 anticorps

Fonction: UBA7 Antibody / Ubiquitin like modifier activating enzyme 7 / Ube1L

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human Ube1L / UBA7 was used as the immunogen for the UBA7 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the UBA7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the UBA7 antibody at -20oC.

Détails sur UBA7

Antigène: UBA7 (Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7))

Autre désignation: UBA7

Sujet: UBA7 antibody detects ubiquitin like modifier activating enzyme 7, an E1 enzyme encoded by the UBA7 gene. UBA7 catalyzes the first step in the ISGylation pathway, activating the ubiquitin like modifier ISG15. This modification resembles ubiquitination but involves the conjugation of ISG15 to target proteins, regulating antiviral responses, immune signaling, and protein stability. By activating ISG15, UBA7 plays a central role in interferon stimulated gene expression and innate immunity.

UBA7 antibody is widely applied in immunology, virology, and cancer biology. UBA7 is induced by type I interferons and mediates host defense against viral infection. ISGylation of viral and host proteins disrupts replication cycles and enhances antiviral resistance. By detecting UBA7, researchers can investigate how interferon pathways regulate protein modification and innate immunity.

Western blot assays detect UBA7 protein in interferon treated cells, while immunohistochemistry maps its expression in immune tissues. Immunofluorescence highlights cytoplasmic and nuclear localization, consistent with its role in protein conjugation. These applications make UBA7 antibody a versatile tool for studying antiviral responses and immune regulation.

Beyond virology, UBA7 contributes to tumor suppression. Loss of UBA7 expression has been linked to lung cancer and leukemia, where reduced ISGylation disrupts normal cell regulation. UBA7 also interacts with ubiquitin conjugating enzymes, linking ISGylation to broader protein quality control mechanisms. By applying UBA7 antibody, scientists can evaluate how ubiquitin like modifications influence cancer biology and immune defense.

UBA7 antibody from NSJ Bioreagents provides dependable specificity for analyzing ISGylation pathways. Its strong performance across applications supports both basic and translational research into immune signaling, antiviral defense, and cancer suppression.

UniProt: P41226