Recombinant Vinculin anticorps

N° du produit ABIN7882681

L’anticorps anti-Vinculin Monoclonal Souris est utilisé pour la détection de Vinculin dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant Vinculin anticorps (ABIN7882681)

Antigène: Vinculin (VCL)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Vinculin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RVCL-7287

Détail du produit anti-Vinculin anticorps

Fonction: Vinculin Antibody

Purification: Protein A/G affinity

Immunogène: A recombinant fragment of human Vinculin (VCL) protein was used as the immunogen for the Vinculin antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Vinculin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Vinculin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Vinculin

Antigène: Vinculin (VCL)

Autre désignation: Vinculin

Sujet: Focal adhesions are identified as areas within the plasma membrane of tissue culture cells that adhere tightly to the underlying substrate. In vivo, these regions are involved in the adhesion of cells to the extracellular matrix. Paxillin and vinculin are cytoskeletal, focal adhesion proteins that are components of a protein complex which links the Actin network to the plasma membrane. Vinculin binding sites have been identified on other cytoskeletal proteins, including Talin and Alpha-Actinin. In addition, vinculin, Talin and Alpha-Actinin each contain Actin binding sites. Expression of vinculin and Talin have been shown to be affected by the level of Actin expression. Alpha-Actinin has been shown to link Actin to integrins in the plasma membrane through interactions with the vinculin and Talin complex or by a direct interaction with integrin.

UniProt: P18206

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2