Vitronectin Receptor anticorps

N° du produit ABIN7882688

Cet anticorps anti-Vitronectin Receptor Monoclonal Souris (Clone 23C6) (ABIN7882688) détecte spécifiquement Vitronectin Receptor dans ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Vitronectin Receptor anticorps (ABIN7882688)

Antigène: Vitronectin Receptor

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: ELISA

Clone: 23C6

Détail du produit

Fonction: Vitronectin Receptor Antibody / Integrin alpha V / ITGAV

Purification: Protein G affinity chromatography

Immunogène: Osteoclasts from osteoclastomas were used as the immunogen for the Vitronectin Receptor antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Vitronectin Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Vitronectin Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: Vitronectin Receptor

Sujet: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.

UniProt: P06756