ADORA1 anticorps (3rd Intracellular Loop)

N° du produit ABIN7884719

Cet anticorps anti-ADORA1 Polyclonal Lapin (ABIN7884719) détecte spécifiquement ADORA1 dans WB, IHC, IF et IC. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour ADORA1 anticorps (3rd Intracellular Loop) (ABIN7884719)

Antigène: ADORA1 (Adenosine A1 Receptor (ADORA1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADORA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Classe de qualité: Carrier-free, KO Validated

Détail du produit anti-ADORA1 anticorps

Épitope: 3rd Intracellular Loop, AA 213-229

Fonction: A Rabbit Polyclonal Antibody to Adenosine A1 Receptor

Homologie: Mouse,rat,bovine,canis,pig - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KKVSASSGDPQKYYGKE, corresponding to amino acid residues 213-229 of human A1AR

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:100

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7234623)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur ADORA1

Antigène: ADORA1 (Adenosine A1 Receptor (ADORA1))

Autre désignation: ADORA1

Sujet:

Synonyms: ADORA1, A1AR, Adenosine A1R

Description: Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including the brain and heart.1,2 Adenosine exerts its actions via four specific adenosine receptors (also named P1 purinergic receptors): Adenosine A1 Receptor (A1AR), Adenosine A2A Receptor (A2AAR), Adenosine A2B Receptor (A2BAR), and Adenosine A3 Receptor (A3AR). All are integral membrane proteins and are members of the G protein-coupled receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important for binding G proteins.1-3 The adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs.1-3A1AR is widely distributed and has been well characterized. High expression of A1AR is found in the brain (mainly in the cortex, cerebellum, and hippocampus), dorsal horn of the spinal cord, adrenal gland, and atria, and to a lower extent in several other tissues including adipose tissue, the colon, and kidney.2,4A1AR modulates the activity of several ion channels. Activation of A1AR (by adenosine, its major agonist) inhibits N-type Ca2+ channels via a voltage-dependent, pertussis toxin (PTX)-sensitive pathway in neurons of the rat major pelvic ganglia (MPG).5Since A1AR is the most prominent adenosine receptor in adipocytes, it has become a natural target for research on obesity, which is a major health problem.6,7 A possible role in cell proliferation and carcinogenesis has also been suggested for A1AR.8-10

ID gène: 134

UniProt: P30542

Pathways: EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Synaptic Membrane