Adiponectin Receptor 1 anticorps (Intracellular, N-Term)

N° du produit ABIN7884736

L’anticorps anti-Adiponectin Receptor 1 Polyclonal Lapin est utilisé pour la détection de Adiponectin Receptor 1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et IHC.

Aperçu rapide pour Adiponectin Receptor 1 anticorps (Intracellular, N-Term) (ABIN7884736)

Antigène: Adiponectin Receptor 1 (ADIPOR1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Adiponectin Receptor 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Adiponectin Receptor 1 anticorps

Épitope: AA 18-31, Intracellular, N-Term

Fonction: A rabbit polyclonal antibody to Adiponectin Receptor 1

Homologie: Rat,human - 13 out of 14 amino acids identical.

Purification: Affinity purified on immobilized antigen.

Immunogène: Peptide (C)GNREADTVELAELG, corresponding to amino acid residues 18 - 31 of mouse AdipoR1

Isotype: IgG

Information d'application

Indications d'application: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Adiponectin Receptor 1

Antigène: Adiponectin Receptor 1 (ADIPOR1)

Autre désignation: AdipoR1

Sujet:

Synonyms: AdipoR1, Progestin And AdipoQ Receptor Family Member 1, PAQR1

Description:

Adiponectin receptor 1 (Adipor1) is a crucial component of the cellular machinery that mediates the metabolic and anti-inflammatory effects of the adipokine adiponectin.

AdipoR1 is part of the PAQR (Progestin and AdipoQ Receptor) family, that is characterized by a seven-transmembrane domain organization with intracellular N-terminus and extracellular C-terminus, which is the reverse topology of the seven-transmembrane topology of G-protein coupled receptors.1,2

Adiponectin is a hormone primarily secreted by adipose (fat) tissue. It plays a crucial role in regulating glucose levels as well as fatty acid breakdown. Adiponectin is also involved in reducing inflammation and improving insulin sensitivity, making it an important factor in metabolic health. AdipoR1 and its paralog AdipoR2, mediate the effects of adiponectin, together with Cadherin-13, also known as T-cadherin (CDH13). Unlike AdipoR1 and AdipoR2, Cadherin-13 is a glycosylphosphatidylinositol (GPI)-anchored protein that lacks a transmembrane domain. It acts as a non-signaling co-receptor for the hexameric and high-molecular-weight forms of adiponectin, especially in cardiovascular tissues.2,3,4

Adipor1 is expressed across a wide range of tissues, reflecting its systemic metabolic role. It is most abundantly expressed in skeletal muscle, a major site for glucose uptake and fatty acid oxidation. It is also present in the liver, heart, adipose tissue, kidneys, and notably, the central nervous system (CNS). This broad expression pattern enables Adipor1 to influence diverse physiological processes from peripheral glucose metabolism to central neuroregulation.2,3

Adipor1 primarily acts as a receptor for both full-length and globular forms of adiponectin. Upon ligand binding, it activates downstream signaling pathways, including AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPARα). These pathways enhance insulin sensitivity, promote fatty acid oxidation, and inhibit gluconeogenesis, thereby contributing to improved glucose metabolism and lipid balance.2,3

In the CNS, AdipoR1 is expressed in various areas of the brain, including the hypothalamus, brainstem, hippocampus, and cortex, regions that are involved in regulating energy homeostasis, cognitive function, and motor coordination.5,6

In the hypothalamus and brainstem, adiponectin is thought to regulate food intake and energy expenditure via AdipoR1-mediated AMP-activated protein kinase (AMPK) signaling, while in the hippocampus Adipor1 has been implicated in cognitive functions such as learning and memory.5,6

Finally, it was found that decreased AdipoR1 expression causes spatial learning and memory impairment and Alzheimer's disease-like pathologies, thus suggesting that the adiponectin-AdipoR1 axis should be considered as a treatment target for Alzheimer's disease, as well as other neurodegenerative disorders.5,6,7

ID gène: 72674

UniProt: Q91VH1

Pathways: AMPK Signaling