Aquaporin 4 anticorps (C-Term, Intracellular)

N° du produit ABIN7884768

Cet anticorps Lapin Polyclonal détecte spécifiquement Aquaporin 4 dans WB, IHC, IF et IC. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour Aquaporin 4 anticorps (C-Term, Intracellular) (ABIN7884768)

Antigène: Aquaporin 4 (AQP4)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aquaporin 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Classe de qualité: Carrier-free

Détail du produit anti-Aquaporin 4 anticorps

Épitope: AA 300-314, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Aquaporin 4 Channel

Homologie: human - 13,15 amino acid residues identical,Mouse - 14

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HVIDIDRGDEKKGKD, corresponding to amino acid residues 300-314 of rat AQP4

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: 1:200

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Aquaporin 4

Antigène: Aquaporin 4 (AQP4)

Autre désignation: WCH4

Sujet:

Synonyms: WCH4, Mercurial-insensitive water channel

Description: Aquaporin 4 (AQP-4) belongs to a family of membrane proteins that allow passage of water and certain solutes through biological membranes. The family is composed of 13 members (AQP-0 to AQP-12).The aquaporins can be divided into two functional groups based on their permeability characteristics: the aquaporins that are only permeated by water and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. AQP-4 together with AQP-1, AQP-2 and AQP-5 belong to the first group1. Little is known about the function of the two newest members, AQP-11 and AQP-12.The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores1.AQP-4 is the major membrane water channel in the central nervous system. The channel is expressed in astrocyte foot processes in direct contact with capillary vessels in the brain suggesting a role in water transport under normal and pathological conditions. Indeed, transgenic mice lacking AQP-4 have reduced brain swelling and improved neurological outcome following water intoxication and focal cerebral ischemia. In contrast, brain swelling and clinical outcome are worse in AQP-4-null mice in models of vasogenic (fluid leak) edema caused by freeze-injury and brain tumor, probably due to impaired AQP-4-dependent brain water clearance2.In addition, it has been recently shown that neuromyelitis optica (NMO), an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord, is caused by the development of an autoantibody directed against AQP-43.

ID gène: 25293

UniProt: P47863

Pathways: Sensory Perception of Sound