Aquaporin 8 anticorps (Intracellular, N-Term)

N° du produit ABIN7884772

L’anticorps anti-Aquaporin 8 Polyclonal Lapin est utilisé pour la détection de Aquaporin 8 dans des échantillons de Souris. Il a été validé pour WB et IHC.

Aperçu rapide pour Aquaporin 8 anticorps (Intracellular, N-Term) (ABIN7884772)

Antigène: Aquaporin 8 (AQP8)

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aquaporin 8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Détail du produit anti-Aquaporin 8 anticorps

Épitope: AA 14-28, Intracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Aquaporin 8 Channel

Homologie: Unlikely to recognize mouse,human samples

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)REIKGKETNMADSYH, corresponding to amino acid residues 14-28 of rat AQP8

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7234779)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Aquaporin 8

Antigène: Aquaporin 8 (AQP8)

Autre désignation: AQP8

Sujet:

Synonyms: AQP8

Description: Aquaporin 8 (AQP-8) belongs to a family of membrane proteins that allow passage of water and certain other solutes through biological membranes.1 The family is composed of 13 members (AQP-0 to AQP-12). Little is known about the function of the two newest members, AQP-11 and AQP-12.The aquaporins can be divided into two functional groups based on their permability characteristics: the aquaporins that are permeated primarily by water and include besides AQP-8, AQP-1, AQP-2, AQP4 and AQP-5, and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. This last group includes AQP-3, AQP-7, AQP-9 and AQP-10.The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores.2AQP-8 is expressed along the gastrointestinal tract including small intestine, colon, pancreas and liver and also in other organs such as testis, lung and kidney.The physiological function of AQP-8 is not entirely clear but studies suggest that it has an important role in colonic water adsorption and hepatocyte bile formation.3,4 Interestingly, AQP-8 expression is markedly altered in gastrointestinal disorders such as ulcerative colitis and inflammatory bowel disease.5

ID gène: 29172

UniProt: P56405