BRS3 anticorps (2nd Extracellular Loop)

N° du produit ABIN7884790

L’anticorps anti-BRS3 Polyclonal Lapin est utilisé pour la détection de BRS3 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC, FACS et LCI.

Aperçu rapide pour BRS3 anticorps (2nd Extracellular Loop) (ABIN7884790)

Antigène: BRS3 (Bombesin-Like Receptor 3 (BRS3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRS3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-BRS3 anticorps

Épitope: 2nd Extracellular Loop, AA 186-201

Fonction: A Rabbit Polyclonal Antibody to Bombesin Receptor 3

Homologie: Rat,mouse - 13,16 amino acids residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)SNVYTFRDPNKNMTFE, corresponding to amino acid residues 186-201 of human BRS3 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:500

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:50

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7234864)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur BRS3

Antigène: BRS3 (Bombesin-Like Receptor 3 (BRS3))

Autre désignation: BB3R

Sujet:

Synonyms: BB3R, BRS3

Description: Bombesin receptor 3 (BB3) is a member of a family of receptors that binds the 14 amino acid peptide bombesin. Bombesin was first isolated from frog skin and it was later established that mammalians express endogenous bombesin like peptides such as gastrin-releasing peptide (GRP) a 27 amino acid homologue and neuromedin B (NMB) a 10 amino acid homologue.1BB1 is the preferred receptor for NMB while BB2 is the preferred receptor for GRP.BB3 was the third member of the bombesin receptors family to be cloned based in its sequence similarity to BB1 and BB2.2 The affinity of BB3 for bombesin is lower than that of the BB1 and BB2 receptors as is its affinity for NMB and GRP. This suggests that the mammalian endogenous ligand for the BB3 receptor remains to be identified.All three bombesin receptors are members of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB3 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization and cell growth.3The physiological function of the BB3 receptor is not clear. However, studies with BB3 receptor deficient mice have shown that the mice develop mild obesity associated with hypertension and reduced metabolic rate.4,5Finally, BB3 receptor expression has been identified in several human tumors most notably lung. BB3 is therefore considered a potential target for the development of both diagnostics and anti-cancer therapies.6

ID gène: 680

UniProt: P32247

Pathways: Feeding Behaviour