Cadherin 13 anticorps (Extracellular, N-Term)

N° du produit ABIN7884803

Cet anticorps anti-Cadherin 13 Polyclonal Lapin (ABIN7884803) détecte spécifiquement Cadherin 13 dans WB, FACS et LCI. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Cadherin 13 anticorps (Extracellular, N-Term) (ABIN7884803)

Antigène: Cadherin 13 (CDH13)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cadherin 13 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-Cadherin 13 anticorps

Épitope: AA 164-178, Extracellular, N-Term

Fonction: A rabbit polyclonal antibody to Cadherin-13 (extracellular)

Homologie: Rat - identical.  Human - 14 out of 15 amino acid residues identical.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DSDRPEGSKFRLTGK, corresponding to amino acid residues 164 - 178 of mouse CDH13

Isotype: IgG

Information d'application

Indications d'application: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Cadherin 13

Antigène: Cadherin 13 (CDH13)

Autre désignation: CDH13

Sujet:

Synonyms: CDH13, Heart Cadherin, H-Cadherin, Truncated Cadherin, T-Cadherin, T-Cad

Description:

Cadherin-13 (CDH13), also known as Heart Cadherin (H-Cadherin) or Truncated Cadherin (T-cadherin), is a member of the cadherin superfamily, a group of calcium-dependent cell adhesion molecules integral to various cellular processes, including tissue development and maintenance.1

Unlike classical cadherins, which are type I membrane proteins that span the cell membrane once, Cadherin-13 is anchored to the cell membrane by a glycosylphosphatidylinositol (GPI)-anchor, making it an atypical cadherin.1,2

Cadherin-13 is predominantly expressed in the nervous system, where it regulates neuronal migration, axon growth, and synaptic connectivity during brain development. It mediates cell adhesion through homophilic interactions, meaning it binds to other Cadherin-13 Molecules on adjacent cells. This adhesive property is crucial for maintaining the structural integrity of neural circuits and facilitating proper brain function.2,3

Alterations in Cadherin-13 expression or function have been linked to various neurodevelopmental and psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and schizophrenia. These associations underscore the critical role of Cadherin-13 in brain function and behavior.3,4

Beyond the nervous system, Cadherin-13 has been implicated in metabolic regulation. It serves as a binding protein for high molecular weight isoforms of adiponectin, an adipose-derived hormone with anti-inflammatory and insulin-sensitizing properties. This interaction is essential for mediating adiponectin's effects on metabolic processes and vascular function.3,5,6

Finally, Cadherin-13 expression is often downregulated in various cancers, including colon and prostate cancers. This downregulation is associated with increased invasive and metastatic potential of tumor cells and poorer prognosis, indicating that Cadherin-13 may function as a tumor suppressor.7

ID gène: 12554

UniProt: Q9WTR5

Pathways: EGFR Signaling Pathway, Cell-Cell Junction Organization