Calcitonin Receptor anticorps (1st Extracellular Loop)

N° du produit ABIN7884806

Cet anticorps anti-Calcitonin Receptor Polyclonal Lapin (ABIN7884806) détecte spécifiquement Calcitonin Receptor dans WB, IF, IC et LCI. L’anticorps est réactif avec des échantillons de Rat et Souris.

Aperçu rapide pour Calcitonin Receptor anticorps (1st Extracellular Loop) (ABIN7884806)

Antigène: Calcitonin Receptor (CALCR)

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calcitonin Receptor est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Calcitonin Receptor anticorps

Épitope: 1st Extracellular Loop, AA 201-215

Fonction: A Rabbit Polyclonal Antibody to Calcitonin Receptor

Homologie: Mouse - identical, human - 14,15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HLVEVVPNGDLVRRD, corresponding to amino acid residues 201-215 of rat CALCR

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7234900)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Calcitonin Receptor

Antigène: Calcitonin Receptor (CALCR)

Autre désignation: CALCR

Sujet:

Synonyms: CALCR, CT receptor, CT-R, C1A/C1B

Description: the calcitonin receptor (CTR) is a class B G-protein coupled receptor (GPCR) that signals via activation of cAMP and protein kinase C (PKC). It is one of 15 human class B GPCRs1,2. Apart from CTR, calcitonin receptor-like receptor (CTLR) is the only other B-class GPCR to bind calcitonin. To date, there are three known human CTR mRNA isoforms arising from alternative splicing3.Calcitonin itself is a peptide hormone that contributes to bone calcification by direct inhibition of osteoclasts which resorb the bony tissue. It is part of a six-member family that has varied functionalities. By binding to receptor activity modifying proteins (RAMPs), CTR and CTLR can form receptors to every member of the calcitonin family. For instance, RAMP1 and CTR construct the calcitonin gene-related peptide (CGRP) receptor.Both CTR and CTLR have seven transmembrane domains, an intracellular C-terminal, and an extracellular N-terminal. To activate the receptors, their N-terminal must first capture the C-terminal of the ligand and then carried to the transmembrane loops where it bestows a conformational change upon them.Besides the bone, CTR has prominent roles in the kidney, CNS, placenta, ovaries, sperm, lung, and in the brain4,5.In osteoclasts, the expression of CTRs declines with age. Interestingly, polymorphism of the CTR gene is strongly associated with decreased fracture-risk in post-menopausal women3,6.

ID gène: 116506

UniProt: P32214

Pathways: cAMP Metabolic Process