CABP1 anticorps (C-Term, Intracellular)

N° du produit ABIN7884808

L’anticorps anti-CABP1 Polyclonal Lapin est utilisé pour la détection de CABP1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB.

Aperçu rapide pour CABP1 anticorps (C-Term, Intracellular) (ABIN7884808)

Antigène: CABP1 (Calcium Binding Protein 1 (CABP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CABP1 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-CABP1 anticorps

Épitope: AA 256-270, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Calcium-Binding Protein 1

Homologie: Mouse,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)REAMRKLLGHQVGHR, corresponding to amino acid residues 256-270 of rat CaBP1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:600

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7234907)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CABP1

Antigène: CABP1 (Calcium Binding Protein 1 (CABP1))

Autre désignation: Calcium-binding protein 1

Sujet:

Synonyms: Calcium-binding protein 1, Caldendrin, Calbrain

Description: Neuronal Ca2+-binding proteins (CaBP1-5) are a subclass of the calmodulin (CaM) superfamily that regulates specific Ca2+ channel targets in the brain and retina. Multiple isoforms of CaBPs are localized in different neuronal cell types and perform specialized roles in sensory transduction and disease processes1.CaBP1-5 proteins have four EF hands that form pairs within the N lobe (EF1 and 2) and C lobe (EF3 and 4). The two lobes are structurally independent and connected by a flexible linker. Whereas all four EF hands bind Ca2+ in CaM, EF2 in CaBP1 does not bind Ca2+, and EF1 has reduced selectivity for Ca2+ over Mg2+. EF3 and EF4 in the C lobe of CaBP1 exhibit canonical Ca2+-induced conformational changes2. CaBP-target interactions induce functional changes distinct from those caused by CaM and may diversify neuronal responses to Ca2+ signals. CaBPs interact with and reshape the functional properties of certain voltage-gated Ca2+ channels (CaVs)3.CaBP1 is the best characterized family member and has been shown to regulate inositol 1,4,5-triphosphate receptors (IP3Rs), P/Q-type voltage-gated Ca2+ channels, L-type Ca2+ channels, and the transient receptor potential channel (TRPC5)4. CaBP1 regulates the currents of CaV1 and CaV2 channels in neurons, photoreceptors, and auditory hair cells. CaBP interactions with CaV1 channels may be required for hearing and vision, as mutations that disrupt these interactions cause blindness and deafness5.

ID gène: 171051

UniProt: O88751

Pathways: Synaptic Membrane, Negative Regulation of Transporter Activity