CABP4 anticorps (Intracellular)

N° du produit ABIN7884810

Cet anticorps Lapin Polyclonal détecte spécifiquement CABP4 dans WB. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour CABP4 anticorps (Intracellular) (ABIN7884810)

Antigène: CABP4 (Calcium Binding Protein 4 (CABP4))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CABP4 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-CABP4 anticorps

Épitope: AA 105-120, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Calcium-Binding Protein 4

Homologie: Rat - identical, human - 14,15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RTYGPLLNRMFGKDR, corresponding to amino acid residues 105-120 of mouse CaBP4

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7234915)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CABP4

Antigène: CABP4 (Calcium Binding Protein 4 (CABP4))

Autre désignation: Calcium-binding protein 4

Sujet:

Synonyms: Calcium-binding protein 4

Description: Neuronal calcium-binding proteins (CaBP1-8) belong to a subclass of the calmodulin (CaM) superfamily and regulate in particular Ca2+ channel targets in the brain and retina1.CaBP4 contains two globular domains (N- and C-lobe) that each contains a pair of EF- hand motifs connected by a central linker. The second EF-hand in CaBP4 lacks conserved residues in the binding loop and is predicted to not bind Ca2+. CaBP4 interacts structurally with the C-terminal region of CaV1.4 and this Ca2+-dependent interaction has been implicated in the modulation of voltage-dependent CaV1.4 activation2.Multiple isoforms of CaBPs are localized in different neuronal cell types and perform specialized roles in signal transduction. The CaBP4 isoform regulates voltage-gated Ca2+ channels in retinal photoreceptor cells. In the eye, CaBP4 is localized at the photoreceptor synaptic terminals in rods and cones3. CaBP4 is essential for the development and maintenance of the photoreceptor synapse, likely through functional modulation of the photoreceptor Ca2+ channels, α1F L-type voltage- dependent calcium channels (CaV1.4), and neurotransmitter release4.Mutations in both CaV1.4 and CaBP4 have been identied in patients suffering from congenital stationary night blindness type 2 (CSNB2), indicating that defects in Ca2+-dependent regulation of CaV1.4 by CaBP4 are closely associated with CSNB2. Indeed, deletion of CaBP4 in the mouse leads to a CSNB2-like phenotype5.

ID gène: 73660

UniProt: Q8VHC5